Sign Up Now!
To sign up for our newsletter or print publications, please enter your contact information below.
First Name *
Last Name *
Email Address (Verify) *
We will request your mailing address on the next page.
We will request your mailing address on the next page.

Conference Correspondent  - ESMO Highlights

Targeting angiogenesis is a well-established treatment strategy in a variety of tumor types, although for ovarian cancer, improvements in progression-free survival (PFS) have been modest. To improve their efficacy, combinations of antivascular agents may be considered. In this phase 1b/randomized phase 2 study, Morgan and colleagues evaluated pazopanib, an oral VEGFR inhibitor, with or without fosbretabulin, an intravenous vascular disrupting agent, in patients with advanced recurrent ovarian cancer.

Patients in the randomized phase 2 study (n = 21) received either 54 mg/m2 fosbretabulin and 600 mg/day pazopanib or 800 mg/day pazopanib alone. Median PFS was numerically greater for the fosbretabulin/pazopanib combination (7.6 months [95% confidence interval (CI), 4.1-not estimated]) than for the pazopanib alone group (3.7 months [95% CI, 1.0-8.1]; hazard ratio, 0.30; 95% CI, 0.08-1.03; P = .06). However, observed cardiac toxicity resulted in premature discontinuation of the trial, as 4 patients who received fosbretabulin/pazopanib (2 [16.7%] in phase 1b [n = 12], and 2 [9.5%] in the randomized phase 2 study) developed acute hypertension plus reversible secondary cardiac toxicity.

Although the fosbretabulin/pazopanib combination showed preliminary efficacy in treating recurrent epithelial ovarian cancer, reversible secondary cardiac toxicity associated with the treatment resulted in the premature discontinuation of the trial. The study investigators suggest that improved hypertension control may have prevented this toxicity.

Source

Morgan RD, et al. ESMO 2018. Abstract 956P.

Related Items
Adjuvant Abemaciclib plus Endocrine Therapy Game-Changer in High-Risk, HR-Positive, HER2-Negative Early Breast Cancer
Phoebe Starr
Web Exclusives published on November 3, 2020 in ESMO Highlights
Trabectedin/PLD versus Carboplatin/PLD in Recurrent Ovarian Cancer Progressing within 6-12 Months After Last Platinum Line
Conference Correspondent  published on September 23, 2020 in ESMO Highlights
Safety and Efficacy of XMT-1536 in Ovarian Cancer: Subgroup Analysis from a Phase 1 Expansion Study
Conference Correspondent  published on September 23, 2020 in ESMO Highlights
Maintenance Olaparib plus Bevacizumab for Newly Diagnosed High-Grade Ovarian Cancer: Second Progression-Free Survival
Conference Correspondent  published on September 23, 2020 in ESMO Highlights
Real-World Data on Platinum Therapy in High-Grade Serous Ovarian Cancer Patients Progressing After PARP Inhibitor Treatment
Conference Correspondent  published on September 23, 2020 in ESMO Highlights
Atezolizumab in Patients with Newly Diagnosed Stage III or Stage IV Ovarian Cancer
Conference Correspondent  published on September 23, 2020 in ESMO Highlights
Mirvetuximab Soravtansine in Combination with Carboplatin and Bevacizumab in Recurrent Ovarian Cancer
Conference Correspondent  published on September 22, 2020 in ESMO Highlights
Patient-Reported Outcomes in Patients Receiving Niraparib in the PRIMA/ENGOT-OV26/GOG-3012 Trial
Conference Correspondent  published on September 22, 2020 in ESMO Highlights
Nivolumab versus Gemcitabine or Pegylated Liposomal Doxorubicin for Patients with Platinum-Resistant Ovarian Cancer: The NINJA Trial
Conference Correspondent  published on September 22, 2020 in ESMO Highlights
Individualized Starting Dose of Niraparib to Treat Platinum-Sensitive Recurrent Ovarian Cancer: The NORA Trial
Conference Correspondent  published on September 22, 2020 in ESMO Highlights
Copyright © Green Hill Healthcare Communications, LLC. All rights reserved.