Sign Up Now!
To sign up for our newsletter or print publications, please enter your contact information below.
First Name *
Last Name *
Email Address (Verify) *
We will request your mailing address on the next page.
We will request your mailing address on the next page.

Conference Correspondent  - ESMO Highlights

Germ-line mutations in BRCA1 or BRCA2 genes are implicated in approximately 15% of ovarian cancers.1 Although this subset of ovarian cancers is generally characterized by a good initial response to chemotherapy, 10-year survival is not different between those with BRCA1/2 mutations and noncarriers.2 In a retrospective analysis of 212 women with relapsed high-grade serous ovarian cancer between 2000 and 2014, Sokolenko and colleagues sought to further evaluate the distinguishing clinical features between hereditary and sporadic ovarian cancer.3

Of the included patients, 113 (53.3%) and 99 (46.7%) underwent complete primary or interval surgical debulking, respectively. Most women (n = 146; 68.9%) were negative for BRCA1/2 germ-line mutations, whereas 66 (31.1%) were carriers of BRCA1/2 mutations. As the investigators expected, the median platinum-free interval (PFI) in BRCA1/2 carriers was longer compared with sporadic cases (13.2 months vs 8.0 months; P <.001). Furthermore, the proportion of ovarian cancer cases with PFI >12 months was significantly higher among BRCA1/2 carriers (38/66 [58%]) compared with patients with sporadic disease (51/146 [35%]; P = .003).

Looking at relapse location, no statistical between-group difference was observed in the frequency of relapses to distant locations (P = .4). However, systemic recurrences (ie, multiple lesions) occurred significantly more frequently in sporadic cases (98/144 [68%]) compared with carriers of BRCA1/2 mutations (30/60 [50%]; P = .02) and were associated with a shorter PFI (P = .003). In addition, a greater proportion of BRCA1/2 mutation carriers than noncarriers could be subjected to local treatment (locoregional discrete recurrence with lymphatic/transcoelomic spread) (29/66 [44%] vs 45/146 [31%], respectively; P = .045).

Taken together, the results of this study indicate that ovarian cancers driven by BRCA1/2 are characterized by a more favorable mode of relapse than sporadic high-grade serous ovarian cancers.


References

  1. Pan Z, et al. Oncotarget. 2017;8(57):97657-97670.
  2. Huang YW. Medicine. 2018;97:2(e9380).
  3. Sokolenko AP, et al. ESMO 2018. Abstract 991P.
Related Items
Adjuvant Abemaciclib plus Endocrine Therapy Game-Changer in High-Risk, HR-Positive, HER2-Negative Early Breast Cancer
Phoebe Starr
Web Exclusives published on November 3, 2020 in ESMO Highlights
Trabectedin/PLD versus Carboplatin/PLD in Recurrent Ovarian Cancer Progressing within 6-12 Months After Last Platinum Line
Conference Correspondent  published on September 23, 2020 in ESMO Highlights
Safety and Efficacy of XMT-1536 in Ovarian Cancer: Subgroup Analysis from a Phase 1 Expansion Study
Conference Correspondent  published on September 23, 2020 in ESMO Highlights
Maintenance Olaparib plus Bevacizumab for Newly Diagnosed High-Grade Ovarian Cancer: Second Progression-Free Survival
Conference Correspondent  published on September 23, 2020 in ESMO Highlights
Real-World Data on Platinum Therapy in High-Grade Serous Ovarian Cancer Patients Progressing After PARP Inhibitor Treatment
Conference Correspondent  published on September 23, 2020 in ESMO Highlights
Atezolizumab in Patients with Newly Diagnosed Stage III or Stage IV Ovarian Cancer
Conference Correspondent  published on September 23, 2020 in ESMO Highlights
Mirvetuximab Soravtansine in Combination with Carboplatin and Bevacizumab in Recurrent Ovarian Cancer
Conference Correspondent  published on September 22, 2020 in ESMO Highlights
Patient-Reported Outcomes in Patients Receiving Niraparib in the PRIMA/ENGOT-OV26/GOG-3012 Trial
Conference Correspondent  published on September 22, 2020 in ESMO Highlights
Nivolumab versus Gemcitabine or Pegylated Liposomal Doxorubicin for Patients with Platinum-Resistant Ovarian Cancer: The NINJA Trial
Conference Correspondent  published on September 22, 2020 in ESMO Highlights
Individualized Starting Dose of Niraparib to Treat Platinum-Sensitive Recurrent Ovarian Cancer: The NORA Trial
Conference Correspondent  published on September 22, 2020 in ESMO Highlights
Copyright © Green Hill Healthcare Communications, LLC. All rights reserved.