Sign Up Now!
To sign up for our newsletter or print publications, please enter your contact information below.
First Name *
Last Name *
Email Address (Verify) *
We will request your mailing address on the next page.
We will request your mailing address on the next page.

Conference Correspondent  - ESMO Highlights

Ovarian carcinoma has the highest mortality rate among gynecologic malignancies, due in part to the primary drug resistance and multidrug resistance that represent major clinical obstacles to treatment.1 Apatinib is a small-molecule tyrosine kinase inhibitor independently developed in China that mainly functions by competitively blocking the binding of VEGF with VEGFR-2 and preventing the autophosphorylation of VEGFR-2. Antitumor effects are thereby elicited by preventing VEGF-mediated endothelial cell proliferation and migration, and reducing tumor angiogenesis. In this prospective, open-label, single-arm clinical trial, Sun and colleagues evaluated the efficacy and safety of apatinib mesylate as treatment after failure of second-line chemotherapy in patients with advanced epithelial ovarian cancer.2

Of 17 evaluable patients who received oral apatinib for 3 treatment cycles (each cycle included 500 mg or 250 mg apatinib once daily for 28 days), 6 (35.3%) and 2 (11.8%) patients achieved partial response and stable disease, respectively. The objective response rate (ORR) and disease control rate (DCR) were 35.3% and 47.1%, respectively. Efficacy signals were not significantly different between groups receiving initial dosages of 500 mg (ORR, 30%; DCR, 30%) and 250 mg (ORR, 42.8%; DCR, 71.4%). The median progression-free survival was 2.2 months (95% confidence interval [CI], 1.0-8.9 months) and the median overall survival was 6.3 months (95% CI, 1.5-12.8 months). The most common adverse events reported were hypertension (70.6%), hand-foot syndrome (52.9%), and oral mucosa damage (35.3%).

The results of this study suggest that oral apatinib treatment is efficacious and well-tolerated in patients with advanced epithelial ovarian cancer who have failed second-line chemotherapy.

References

  1. Norouzi-Barough L, et al. J Cell Physiol. 2018;233(6):4546-4562.
  2. Sun S, et al. ESMO 2018. Abstract 974P.
Related Items
Adjuvant Abemaciclib plus Endocrine Therapy Game-Changer in High-Risk, HR-Positive, HER2-Negative Early Breast Cancer
Phoebe Starr
Web Exclusives published on November 3, 2020 in ESMO Highlights
Trabectedin/PLD versus Carboplatin/PLD in Recurrent Ovarian Cancer Progressing within 6-12 Months After Last Platinum Line
Conference Correspondent  published on September 23, 2020 in ESMO Highlights
Safety and Efficacy of XMT-1536 in Ovarian Cancer: Subgroup Analysis from a Phase 1 Expansion Study
Conference Correspondent  published on September 23, 2020 in ESMO Highlights
Maintenance Olaparib plus Bevacizumab for Newly Diagnosed High-Grade Ovarian Cancer: Second Progression-Free Survival
Conference Correspondent  published on September 23, 2020 in ESMO Highlights
Real-World Data on Platinum Therapy in High-Grade Serous Ovarian Cancer Patients Progressing After PARP Inhibitor Treatment
Conference Correspondent  published on September 23, 2020 in ESMO Highlights
Atezolizumab in Patients with Newly Diagnosed Stage III or Stage IV Ovarian Cancer
Conference Correspondent  published on September 23, 2020 in ESMO Highlights
Mirvetuximab Soravtansine in Combination with Carboplatin and Bevacizumab in Recurrent Ovarian Cancer
Conference Correspondent  published on September 22, 2020 in ESMO Highlights
Patient-Reported Outcomes in Patients Receiving Niraparib in the PRIMA/ENGOT-OV26/GOG-3012 Trial
Conference Correspondent  published on September 22, 2020 in ESMO Highlights
Nivolumab versus Gemcitabine or Pegylated Liposomal Doxorubicin for Patients with Platinum-Resistant Ovarian Cancer: The NINJA Trial
Conference Correspondent  published on September 22, 2020 in ESMO Highlights
Individualized Starting Dose of Niraparib to Treat Platinum-Sensitive Recurrent Ovarian Cancer: The NORA Trial
Conference Correspondent  published on September 22, 2020 in ESMO Highlights
Copyright © Green Hill Healthcare Communications, LLC. All rights reserved.