JHOP - Sept 2016 Vol 6, No 3
The Effect of Written Pharmacist-Provided Patient Education for 3 Frequently Prescribed Oral Anticancer Agents on the Incidence of Patient-Initiated Triage Calls
Nicolas De Padova, PharmD, Robert Grabowski, PharmD, Joseph Ineck, PharmD, Robert S. Mancini, PharmD, BCOP
Austin J. Combest, PharmD, BCOP, MBA, Ryan C. Danford, PharmD, Elizabeth R. Andrews, PharmD, Ashley Simmons, PharmD, Paulina McAtee, PharmD, Dirk J. Reitsma, MD
Pemetrexed (Alimta) is a pyrrolopyrimidine-core folate analog metabolic inhibitor that disrupts the folate-dependent metabolic processes essential for cell replication. Pemetrexed exhibits its antineoplastic activity by inhibiting several key enzymes in the de novo synthesis of purine and pyrimidine nucleotides in neoplastic cells, resulting in cellular cytotoxicity.
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